/eagle1S

Re-implementation of EAGLE using Stan.

Primary LanguageR

eagle1S

Re-implementation of EAGLE using Stan: https://mc-stan.org/

Original EAGLE

The original EAGLE codebase is here: https://github.com/davidaknowles/eagle and the accompanying paper is here: http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4298.html

Getting started

The easiest way to install will be using devtools

if (!require("devtools")) install.packages("devtools", repos='http://cran.us.r-project.org')
devtools::install_github("davidaknowles/eagle1S/eagle1S")

You will need the packages tidyverse, magrittr, doMC and intervals to run the example code.

Then clone this repo somewhere and look in example/. simulate.Rmd simulates a synthetic dataset on chromosome 22 and fit_per_snp.Rmd runs EAGLE on the simulated data. This will give you appropriate input files to try to match for your data.