/autoimmune_treatments

Cataloging current autoimmune treatments.

Autoimmune Treatments

To date, besides some exceptions, autoimmune diseases cannot be cured, only treated.

This repo attempts to compile the current treatments for autoimmune diseases as well as possible cures. Notes and literature sources are included.

1. Cell Depletion

  • B Cell
    • Antibody
    • CAR-T Therapy
      • CD19 - (complete remission in all 5 patients with severe SLE)
      • BCMA (B cell maturation antigen) - No research yet,
  • T Cell
    • Antibody
      • CD3ε
        • Muromonab-CD3 (Orthoclone OKT3)

2. Cellular Inhibition

  • Corticosteroids
    • Prednisone
    • Methylprednisone
    • Dexamethasone
    • Hydrocortisone
    • Budesonide (Pulmicort)
  • JAK (Janus kinase) Inhibitors
    • Tofacitinib (Xeljanz)
    • Upadacitinib (Rinvoq)
    • Abrocitinib (Cibinqo)
    • Baricitinib (Olumiant)
    • Filgotinib (Jyseleca)
    • Ruxolitinib (Jakafi / Jakavi)
    • Peficitinib (Smyraf)
    • Pacritinib (Vonjo)
    • Oclacitinib (Apoquel)
    • Fedratinib (Inrebic)
    • Delgocitinib (Corectim)
  • Purine Synthesis Inhibitors
    • Azathioprione (Imuran)
    • Mycophenolic acid (CellCept)
    • Mercaptopurine (Purinethol)
  • Pyrimidine Synthesis Inhibitors
    • Fluorouracil (Adrucil)
    • Teriflunomide (Aubagio)
    • Leflunomide (Arava)
  • Calcineurin Inhibitors
    • Tacrolimus (Prograf)
    • Ciclosporin
  • mTOR inhibitors
    • Rapamycin (Sirolimus)
    • Temsirolimus (Torisel)
    • Everolimus (Afinitor)
    • Ridaforolimus
    • Umirolimus (Biolimus)
    • Zotarolimus
  • Other
    • Cyclophosphamide - alkylating mustard agent
    • Methotrexate (MTX) - dihydrofolate reductase inhibitor
    • Fingolimod (Gilenya) - sphingosine-1-phosphate receptor modulator
    • Myriocin (ISP-1 / thermozymocidin) - serine palmitoyltransferase inhibitor

3. Cytokine Inhibition * BAFF (B-cell activating factor)

  • BAFF
    • Belimumab (Benlysta)
  • Interferon type I
  • TNFα
  • IL-1
  • IL-4
  • IL-5
  • IL-6
  • IL-12
  • IL-13
  • IL-17
  • IL-23

4. Cytokine Therapy

  • TGFβ
  • IL-10
  • IL-35

5. Antibody Reduction

  • Plasmapharesis
  • IVIg (intravenous immunoglobulin)

6. HSC Transplantation

7. Microbiome Alteration

https://pubmed.ncbi.nlm.nih.gov/35534624/

8. Treg Engineering