inbox.todo:

- check that the noradrenaline dose differences are not due to how methods of weight adjustment
	we don't have the raw doses in the spreadsheet just the weight adjusted doses so if weight adjustment was done using IBW vs actual BW in Italy we would not know @discuss

next.todo:

- exp

later.todo:

- heart rate important early
- sedation important relationship with hospital mortality
	- high sedation and high noradrenaline use
- sepsis definitions and lactate plus or minus hypotension

Data questions following on from the new 8 ICU sheet
- missing BMI data (prob just need to recalc)
- missing n_days_fb hence can't calculate cumulative fluid balanceurr
- error (y) in pmh_bblocker (corrected by hand)
- missing mortality outcomes for 11% ?which hospitals

Issues

2015-11-24

heights from Royal London are in metres not cm

From phone call 2014-11-30

TODO: 2014-11-30 - [ ] @steve check pattern of intubation by site (proportions) - how? there is no field? could use PEEP field or sedation field TODO: 2014-11-30 - [ ] @steve report sample size by site TODO: 2014-11-30 - [ ] @steve noradrenaline and heart rate; TODO: 2014-11-30 - [ ] @steve heart rate and noradrenaline (cut at 95), on mortality (interaction) TODO: 2014-11-30 - [ ] @steve lactate and mortality (compare at 1hr and 24hr); running smooth (no model initally ?inflexion) TODO: 2014-11-30 - [ ] @merv chase Paris @done(2015-04-08) TODO: 2014-11-30 - [ ] @merv check re beta-block in Belfast @done(2015-04-08) TODO: 2014-11-30 - [ ] @merv check re physiology in Rome @done(2015-04-08) TODO: 2014-11-30 - [ ] @roberta-sara add in Paris data @done(2015-04-08) TODO: 2014-11-30 - [ ] @roberta-sara add in Tommy's data @done(2015-04-08)

General

TODO: 2014-11-30 - [ ] @steve cardiac output monitoring use TODO: 2014-11-30 - [ ] @steve temperature TODO: 2014-10-13 - [ ] this is not being treated as a catvar @priority(3) TODO: 2014-10-13 - [ ] fix sepsis.site @priority(3) TODO: 2014-10-13 - [ ] @roberta-sara check for ne_start fr 2008? TODO: 2014-10-13 - [ ] @roberta-sara decide which bugs you want reported (will need cleaning) TODO: 2014-11-12 - [ ] @roberta-sara correct fin.24 outliers at 30, 44, 9 TODO: 2014-11-12 - [ ] correct fin.cum outliers at 12.2 -- 180 ? or correct for LOS TODO: 2014-11-23 - [ ] converting to numeric; check this is OK TODO: 2014-11-29 - [ ] email requests @done(2014-11-30) TODO: 2014-10-13 - [ ] @roberta-sara check for ne_start fr 2008?

Paper outline

Notes

Figures

Log

Email from Roberta 15 March 2015

Dear Mervyn, Greetings from Ancona!! The datasheet has still got some question marks, but we eventually decides to stop asking for answers, looking forward to have good news from Steve :-)

Paris misses important info as BP and Bugs, but we think other data are interesting ( they reach high levels of noradrenaline, not using any other vasoactive drugs at all. Disappointing: why did they include patients without noradrenaline if we asked for patients on NE?!!);

St Thomas sent us just 40 people but they are more or less complete;

Leeuwarden didn't answer about FB ( could you ask dr Boerma please? They are our outlier we have to know why ;-)

Half of the patients Rome sent us are from 2008 - ( on the contrary we asked for patient admitted during the previous two years ...so 2011-2012-2013) . Is it a problem? Guidelines were similar but not the same

I partecipated the meetings Dr Girardis organized to plan for the new italian multicentre trial about b blockade in septic shock - still far from starting - and dr Morelli spoke about the retrospective study we are "finishing", asking for good advices. They will include patients admitted in ITU for septic shock or developing it during the stay, they will probably exclude people with less than 0.1 mcg/kg/min of NE thinking that low rate NE is just related to sedation, but they are discussing about using a sedation score as we are. B-blockers will be used for patients that stay tachycardic after fluid resus but.... interestingly they are thinking that the threshold of 95 BPM is too low and 100 is probably better. Something useful also for us but we think we have to Skype together with Steve and you, Mervyn. Is that alright for you?

Bw, R+S+new baby+doggy

docsteveharris/collab-norad