/LS-88-Genomics

Class materials for LS 88-3 Genomics and Data Science

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Genomics-DataScience

Fall 2016
Instructor: Shishi Luo
Office Hours: Thu 10-11am, 418 Evans Hall
This github contains the class materials for LS 88-3 Genomics and Data Science
If you have trouble obtaining some of the readings via the links, you can find the pdfs on the bcourses site.

Calendar (subject to change)

Date Lecture Notes
Aug 30 Intro 1: Let's start at the very beginning Reading: Mystery of the devious defecator
Sep 6 Intro 2: How is genetic data generated? Lab: Exploratory analysis of genome sizes, Reading: Genetic tests to minimize chemotherapy
Sep 13 HIV 1: The Berlin patient and the Mississippi baby Readings: The following reviews on HIV/AIDs Nature Review Genetics review, The Lancet review
Sep 20 HIV 2: The HIV genome Lab: Starts and stops in the HIV genome
Sep 27 HIV 3: A tale of two genes Lab: Variation in the Env and Pol genes, Reading: Guilty Sequence
Oct 4 HIV 4: Forensic Phylogenetics Lab: Matching the HIV sequence to the patient, Reading: My Genome, My Self
Oct 11 Personal Genomics 1: There's a SNP for that Group project proposal due at beginning of class. Lab: Pre-processing phenotype data
Oct 18 Personal Genomics 2: The statistics behind genome-wide association studies Lab: Mini GWAS
Oct 25 Personal Genomics 3: The ethics of genetic testing for health and ancestry Special guest lecture postponed to Nov 15
Nov 1 Forensics 1: The genetics of innocence Lab: CODIS data set, watch this TED talk
Nov 8 Forensics 2: The genetics of guilt
Nov 15 Forensics 3: Historical samples Brian Johnsrud will talk about his fieldwork in genetic ancestry studies in Israel and Lebanon
Nov 22 Group presentations
Nov 29 Group presentations Due date for project report and code

Assessment

Component % of grade Notes
Participation 25%
Labs (completion only) 25%
'Genomics & data science in the news' 10% presentation and write-up
Group project 40% written proposal (10%), final write-up and presentation (30%)