BioVU Data Analysis

The goal of the project is to study the association between mtDNA haplogroups and delirium in sepsis patients.

Statistical modeling (regression and mediation analysis)

Haplogroup: Mito Delirium BioVU Data/Genetics/CAM_Haplogroups.xlsx
Date of death (DOD): Mito Delirium BioVU Data/Demographics/Date of Death data.xlsx (sheet FINAL DATE OF DEATH DATA)
All cohort subjects: datafile/sepsis_grids_20200106.xlsx (sheet All GRIDs)
Admission & discharge dates (include worst sofa score per admission): datafile/sepsis_compare_20191217.csv
Daily CAM status: datafile/daily_status_20190925.csv
Daily lab (includes sofa, rass, creatinine, platelet ...): datafile/daily_sofa_score_20191010.csv
Neuro damage data (remove encounters with "bad" icd codes):
- ICD9: Mito Delirium BioVU Data/Neuro Exclusions/neuro_icd9_V2.xlsx
- ICD10: Mito Delirium BioVU Data/Neuro Exclusions/neuro_icd10_V2.xlsx
Comorbidity score: Mito Delirium BioVU Data/Elixhauser Comorbidities/*.xlsx
Daily dementia: Mito Delirium BioVU Data/Dementia/Dementia.xlsx (sheet Initial Dementia Code date)
Medications
- Mito Delirium BioVU Data/Data/grid_date_med1.csv
- Mito Delirium BioVU Data/Data/grid_date_med2.csv
- Mito Delirium BioVU Data/Data/grid_date_med3.csv
In ICU death manual review: datafile/in_ICU_death_manual_review.txt

Data dictionary: data_arxiv/analysis_daily_dict.xlsx
Daily-level data: data_arxiv/analysis_daily.rds
Encounter-level data: grid and adm_date in daily-level data uniquely determine an encounter
Subject-level data: grid in daily-level data uniquely determine a subject