/twins-analysis

Causal analysis of twin health outcomes

twins-analysis

Causal analysis of twin health outcomes

Research Questions

  1. Does mother’s health have an impact on the difference in birth weight of twin pairs?

  2. Does birth weight have an impact on mortality rate?

  3. Does birth order have an impact on birth weight?

  4. Does mother’s health have an impact on the risk of twins developing chromosomal abnormalities?

Files

data_wrangling.Rmd: Clean and wrangle data matching_pairs.Rmd: Match twins from the individual observations/rows and output matched dataset to twins2013_matched_children.csv eda.Rmd: Exploratory data analysis

How to run the files

Run matching_pairs.Rmd to ouput a CSV with matched children. Run eda.Rmd which takes as input the matched CSV (output from matching_pairs.Rmd) and visualizes the data.

Subsetting the original dataset

  • the orininal denominator and numerator are downloaded from the ncbi website.
  • using the DPLURAL variable (with levels singleton, twin, triplets, etc.) to subset it only to data without singletons
  • use a long string of covariates to match observations with the same set of covariates (Note that the number and identifier are basically the same thing. Just want to have something easier to refer to so I added the number)
  • I was being conservative one picking the set of covariates by looking at the table with numbers of twins, triplets, ... in the our matched sample compared to what the orginal data reported in DPLURAL. By conservative, I meant I want our numbers to be no larger than what they reported.
  • This result in ~89.5% of matched samples which is similar with 90.5% reported in the paper for a different year.

Subsetting the matched data to data with birth order info

  • I only subset it by looking at the number of unique birth orders match with the number of babies in that birth (e.g. for triplets, they should have 3 distinct birth orders)
  • This is not perfect as explained in our meeting. Can work more on it later.

Presentations

Initial project overview: https://docs.google.com/presentation/d/1mMjyNRkq14cksO3MPji0mi4Vsnqf55Rp1gwpX0l6-7M/edit?usp=sharing Final presentation: https://drive.google.com/file/d/14LfvehJNgT5GVQfMS5rDDAjpYzbQ61Qs/view?usp=sharing

Final Report

https://docs.google.com/document/d/1elpzq_1SMYpzoXjyAIYY9nNp4tq2M9rhyR_pgaxh-Xs/edit?usp=sharing