/Deep-Learning

Ongoing deep learning research applied to mulit-omic genetic data

Primary LanguageJupyter Notebook

Deep-Learning

  1. CNN-LSTM model on DNA sequence
    • Hybrid CNN and bidirectional LSTM RNN structure to predict DNA sequences to binary output
    • Achieved 94% test accuracy
  2. Multimodal-MARS: Variational autoencoder based models for single cell annotation
    • Incorporated VAE and CVAE models into MARS-single cell autoencoder based model (Brbic et al. 2020)
    • Achieved improved modality integration between single cell RNA and ATAC seq data
    • Enhanced label transfering from single cell RNA to highly sparsed ATAC seq data
    • Achieved better clustering boundaries than AE based MARS for multi-modal single cell annotation

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  1. GRU-based multi head model to predict microbe-host and microbe-microbe interactions
    • Achieved multi-tasking classification of host disease state
    • Achieved autoregressive time seires prediction of microbial relative abundance at different taxonomy levels
    • Created in-silico experiments to test perturbation effects

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