or single cell variational inference of the Human Heart. here I reproduce a single-cell variational model and analysis of the Nature paper of Litviňuková et al. (2020).
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D.,Worth, C. L., Lindberg, E. L., … & Teichmann, S. A. (2020). Cells of the adult human heart. Nature, 588(7838), 466-472.
single cells, nuclei and CD45+ enriched cells from the left and right ventricular free walls, left and right atrium, the left ventricular apex, and interventricular septum, from 14 adults. After processing with 10X Genomics and a generative deep variational autoencoder, the resulting dataset comprises 45,870 cells, 78,023 CD45+ enriched cells and 363,213 nuclei for 11 major cell types:"
- atrial cardiomyocytes,
- ventricular cardiomyocytes,
- fibroblasts (FBs),
- endothelial cells (ECs),
- pericytes, smooth muscle cells (SMCs),
- immune cells (myeloid and lymphoid),
- adipocytes,
- mesothelial cells
- and neuronal cells
mapping out the genomics data as represemted by Litviňuková et al. (2020) in Nature.