This repo stores some notes.
Existing topics are:
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Hypothesis testing:
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Different testings, such as t-test, binomial test and chisq test
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Concepts in testing, such as chance (tolerance probability)
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MDD and related concepts
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Conditional power (work in progress)
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Survival analysis:
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basic concept, logrank test and Cox's PH model
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Bayesian parametric model and Go/Nogo design
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Fisher's information
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Some random variable distributions:
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Gamma and Beta distribution
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Poisson and negative binomial distribution
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misc information, such as STDM and ADAM, etc.
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Some Bayesian concepts, such as prior/posterior distribution, prior/posterior predictive distribution and different methods to get credible interval.
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to be added.
Upcoming topics are:
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Some Bayesian monitoring concepts, for categorical/TTE end points go/nogo design.
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BOIN and BLRM in early stage design, for single agent or combo agents.
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Multiple testing: gatekeeping, fixed-sequence, fallback, close-set testing procedure
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Multiple imputation: classic MI and Rubin's rule, joint model(JM) and full conditional specification(FCS, MICE), reference/control based MI
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Mixed model: MMRM, etc.
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Alpha spending functions