MuleBot is an IRC bot written in NodeJS. It supports hot code reloading of its plugins, i.e. any changes made to a plugin can be immediately applied by simply reloading the plugin - without restarting the bot.
Simply clone the repository and set up the config-files in the cfg folder.
The most important config-file is options.js, which contains the host and port of the IRC server to connect to. It also contains the nick (and optionally user and name) that the bot should connect as, and a list of channels that the bot should join.
In admins.js you can specify the user, host, and nick information of all IRC users that you want the bot to consider as admins. Admins have access to certain plugins and features that normal users don't have access to.
When the bot has been configured, simply run node main.js. When the bot has connected, test to see if it works by typing !ping in one of the channels.