/Multi-Omic_Network_Integration_Maize

Primary LanguageShellMIT LicenseMIT

Multi-Omic_Network_Integration_Maize

This repository contains a description of primary data, processed data, and codes used to obtain the main results/figures of this project.

Graphical abstract

Main sections

1. Data_pre-processing

2. Construction of a Maize regulatory network based on multiple layers

  • Coexpression network (CEN)
  • Gene association network based on trans-eQTLs (GAN)
  • Gene-regulatory network (GRN), and cis-eQTLs overlapped with GRN interactions (eGRN)

3. TF Functional annotation

4. Evaluation of functional prediction with knockouts

5. Evaluation of functional prediction by comparing with random network

6. Prioritization of regulators by biological process

7. Topological properties predict TF homeologs redundancy