These datasets is used by our experiments. 1) Monthly incidence of hepatitis E from January 2005 to December 2017 was shown by file month_rate.xlsx. 2) Monthly cases number of hepatitis E from January 2005 to December 2017 was shown by file month_number.xlsx. Notes: Due to laws and regulations, we are unable to provide the original data. We provide normalized data for readers to reproduce the experimental results.