/FGFP_BMI_MR

Scripts for running the FGFP BMI on 16S gut microbiome variation MR analyses.

Primary LanguageRMIT LicenseMIT

FGFP BMI --> Microbiome

research question

Does elevated levels of adiposity, as measured by BMI, have an observational and causal effect on gut microbiome variation?

objective

A one-sample MR of BMI(GRS) to microbiome traits, using the FGFP data set.

Here we will be evaluating the observational and causal relationship between BMI-G(R)S and each mirobiome trait (PA, AB, diversity, and enterotypes), individually.

study

  1. Flemish gut flora project (FGFP)
    • data from the lab of Jeroen Raes.
  2. N = ~2200

study data

  1. microbiome traits
  2. clinical/questionarie data
    • BMI
    • age
    • sex
    • SES
    • smoking
  3. genotype data for BMI associated SNPs
    • Yengo et al; n = 656
    • Pulit et al; n = 670

developers

  1. David A Hughes
  2. Kaitlin Wade
  3. Charlie hatcher