A wrapper method to measure cell-to-cell variability in scRNA-seq data.
Each method/metric follows the vignette or paper description. Based on our evaluation paper, we suggest data has at least 50 cells per cell type to obtain reliable estimation.
devtools::install_github("huiwenzh/scVar")
library(scVar)
dat <- matrix(runif(n=1000), nrow=5000)
# use CV
dat_CVvar <- scVar(dat,norm=T,metric='CV')
# use scran
dat_scranvar <- scVar(dat,norm=F,metric='scran')