Refactor ADPC dataset to include urine data
Closed this issue · 2 comments
ayogasekaram commented
PKCL02 listing requires urine drug concentration observations to create the template. PCTPT values for these observations should also be an interval (ex. 0-4H). A ASMED or PCSPEC column may need to be added to differentiate between "PLASMA" and "URINE" values.
legrasv commented
PCSPEC = "URINE", PARAM = "Urine Plasma Drug X" or "Urine Plasma Drug Y" PCTPT = "0-4H" "4-8H" "8-12H" "12-24H" "24-48H"
In reality, the drug does not usually go in the urine in the first 4 hours, so it's usually BLQ 0-4H, then it's quite high around 1500 in average AT 4-8H, then it goes down 300 at 8-12H and almost nothing later, it's like the PK curve but the peak is at 4-8H
AVAL should start at 0 at 0