Last update 3/24/2023
This is a repository for age-related disease (ARD) and trait (ART) set.
Fig. Aging is the single greatest risk factor for age-related disease, and it is well established that conserved genetic pathways of aging impact multiple age-related pathologies in model organisms, but the role of conserved pathways of aging in human age-related disease is unclear.
The MeSH metadata8 provides a standardized vocabulary of medical terms with hierarchical categories, including biomedical information, including diseases, anatomy, chemicals and drugs, phenomena and processes, etc. (Lowe and Barnett, 1994). The 463 ARTs were queried to both the ‘‘Search’’9 and ‘‘MeSH on Demand’’10 functions on the MeSH webpage. The ART-MeSH term pairs are equivalent 1-to-1 matches with the following 4 non-equivalent pair instances;
- (1) some specific traits with no equivalent MeSH terms are mapped to parental MeSH terms (e.g., “Fracture of hand or wrist” mapped to “fracture” in MeSH terms);
- (2) some non-disease ARTs with no equivalent MeSH terms are alternatively mapped to MeSH anatomy, chemical, diagnosis, or phenomena terms (e.g., “Abnormal chest sounds” and “Stiffness of joint” mapped to “thorax” and “ankle joint” in MeSH terms, respectively);
- (3) co-morbidity traits with a common cause are mapped to the causal MeSH disease (e.g., “Hypertensive heart and/or renal disease” mapped to “hypertension” in MeSH terms); and
- (4) some ambiguous co-morbidity traits are mapped to one of those equivalent MeSH disease terms (e.g., “Cardiac arrest & ventricular fibrillation” mapped to “heart arrest” in MeSH terms). The ARTs were also independently mapped to relative MeSH anatomy terms by a 1-to-1 match. Some co-morbidity traits are mapped to one selected disease tissue (e.g., “cancer of kidney and urinary organs” mapped to “kidney” in MeSH terms).
This resources collectively includes 623 ARDs and ARTs mapped with 365 MeSH terms. Below 15 traits were excluded from the original list, because 8 traits from Chang 2019 and 7 traits from Donertas 2020 were irrelevant (e.g., 2 congenital diseases, 8 injuries, and a trauma) or unclear (5 traits).
Table S1. 15 excluded traits
| Study | Trait | Reason for exclusion |
|---|---|---|
| Chang 2019 | Congenital musculoskeletal and limb anomalies | Congenital disease |
| Chang 2019 | Digestive congenital anomalies | Congenital disease |
| Chang 2019 | Drowning | Injury |
| Chang 2019 | Environmental heat and cold exposure | Injury |
| Chang 2019 | Falls | Injury |
| Chang 2019 | Foreign body in other body part | Injury |
| Chang 2019 | Other transport injuries | Injury |
| Chang 2019 | Other unintentional injuries | Injury |
| Donertas 2020 | Haematology | Unclear trait |
| Donertas 2020 | Liver/biliary/pancreas problem | Unclear trait |
| Donertas 2020 | Muscle or soft tissue injuries | Injury |
| Donertas 2020 | Muscle/soft tissue problem | Unclear trait |
| Donertas 2020 | Musculoskeletal/trauma | trauma |
| Donertas 2020 | Neck problem/injury | Injury |
| Donertas 2020 | Neurology/eye/psychiatry | Unclear trait |
Table 1. Count of MeSH by studies
| Study | Count of ARTs |
|---|---|
| Kim 2021 | 463 |
| Chang 2019 | 81 |
| Donertas 2021 | 69 |
| Johnson 2015 | 36 |
| Grand Total | 649 |
Table 2. Count of MeSH by categories
| MeSH category | Count of MeSH term |
|---|---|
| Disease | 329 |
| Chemical | 11 |
| Diagnosis | 9 |
| Anatomy | 8 |
| Phenomena | 5 |
| Psychiatry | 3 |
| Grand Total | 365 |
Table 3. Count of MeSH by groups
| MeSH group | Count of MeSH term |
|---|---|
| Neoplasms | 57 |
| Cardiovascular Diseases | 46 |
| Nervous System Diseases | 32 |
| Male Urogenital Diseases | 24 |
| Musculoskeletal Diseases | 24 |
| Eye Diseases | 21 |
| Digestive System Diseases | 20 |
| Respiratory Tract Diseases | 17 |
| Pathological Conditions, Signs and Symptoms | 14 |
| Nutritional and Metabolic Diseases | 14 |
| Skin and Connective Tissue Diseases | 12 |
| Infections | 12 |
| Chemical | 11 |
| Endocrine System Diseases | 9 |
| Diagnosis | 9 |
| Hemic and Lymphatic Diseases | 8 |
| Anatomy | 7 |
| Otorhinolaryngologic Diseases | 7 |
| Phenomena | 5 |
| Female Urogenital Diseases and Pregnancy Complications | 4 |
| Wounds and Injuries | 3 |
| Psychiatry | 3 |
| Amino Acids, Peptides, and Proteins | 2 |
| Stomatognathic Diseases | 2 |
| Behavior and Behavior Mechanisms | 1 |
| Digestive System | 1 |
| Grand Total | 365 |
Table 4. Count of MeSH by anatomy categories
| Anatomy category | Count of MeSH term |
|---|---|
| Cardiovascular System | 49 |
| Nervous System | 41 |
| Digestive System | 40 |
| Urogenital System | 39 |
| Hemic and Immune Systems | 30 |
| Sense Organs | 29 |
| Respiratory System | 27 |
| Fluids and Secretions | 25 |
| Musculoskeletal System | 23 |
| Unspecified | 21 |
| Integumentary System | 18 |
| Body Regions | 9 |
| Endocrine System | 8 |
| Connective Tissue | 5 |
| Epithelium | 1 |
| Grand Total | 365 |
ARD.tsv: Merged table for ARDs and ARTs by studies [Download]ARD_MeSH.tsv: Pivot table for unique MeSH terms [Download]ARD-v4.xlsx: Original working excel file [Download]
If you use this resource, please cite below all reference.
| Author | Cite |
|---|---|
| Kim 2021 | Kim, Seung-Soo, et al. "A compendium of age-related PheWAS and GWAS traits for human genetic association studies, their networks and genetic correlations." Frontiers in Genetics 12 (2021): 842. Doi: 10.3389/fgene.2021.680560 |
| Donertas 2021 | Dönertaş, Handan Melike, et al. "Common genetic associations between age-related diseases." Nature Aging 1.4 (2021): 400-412. Doi: 10.1038/s43587-021-00051-5 |
| Chang 2019 | Chang, Angela Y., et al. "Measuring population ageing: an analysis of the global burden of disease study 2017." The Lancet Public Health 4.3 (2019): e159-e167. Doi: 10.1016/S2468-2667(19)30019-2 |
| Johnson 2015 | Johnson, Simon C., et al. "Genetic evidence for common pathways in human age‐related diseases." Aging cell 14.5 (2015): 809-817. Doi: 10.1111/acel.12362 |