/Liver-Model-Manuscript

QSP model of liver lipid metabolism for 2022 publication.

Primary LanguageJuliaApache License 2.0Apache-2.0

Liver-Model-Manuscript

QSP model of liver lipid metabolism for 2022 publication.

Execution

  • setup.jl - Will initialize the project, this step can be slow, especially the first time, hence we have split it from the main script.
  • main.jl - Main project script, executing this script will generate the figures from the manuscript.

Additional Functions

  • derived_parameters.jl - Pluto notebook where we derived some of the baseline parameter values from the model. Load by launching Pluto and opening this notebook.
  • dxdt.jl - ODEs of the model
  • lit_std_sim.jl - Script for deriving some values from digitized literature. Not essential for program execution.
  • lognormal_util.jl - Useful functions for lit_std_sim.jl. Not essential for program execution.
  • mh_sim.jl - Function for simulating and scoring the model within the Metropolis-Hastings
  • mh.jl - Main Metropolis-Hastings function used for generating plausible patients.
  • select_vps - Acceptance/rejection sampling of plausible patients to virtual patients
  • util.jl - Some shorter, misc. functions that were needed.

Most recent release: DOI