/iECAT

Integrating external controls into association test

Primary LanguageR

iECAT R-package

iECAT is an R-package for a method to integrating external controls in rare variant tests. It has functions for gene-based tests, including SKAT, and SKAT-O, and single variant test.

Link

Recommended Controls

  • Michigan Genomics Initiative Link
  • UK Biobank Link
  • NHLBI Exome Sequencing Project (ESP) Link

Reference

  • Lee, S., Kim, S., & Fuchsberger, C. (2017). Improving power for rare‐variant tests by integrating external controls. Genetic epidemiology, 41(7), 610-619.