/Hayes_2022

Hayes LN, An K, Carloni E, Li F, Vincent E, Trippaers C, Paranjpe M, Dölen G, Goff LA, Ramos A, Kano S, Sawa A. Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry.

Hayes et al. 2022

All Analyses are in gh-pages branch

Results and Scripts for Hayes et al. 2022 Nature can be found here: https://lindsaynhayes.github.io/Hayes_2022/

Data Analyses

RNA sequencing analysis of microglia in Fig 1 & Ext Data Fig 1-3:

MIA IL-6 serum resonse to LPS Fig 1g: link | script

MIA microglia morphology in Fig 1 & Ext Data Fig 4:

Single Cell RNA sequencing in Fig 1, 4, & Ext Data 5: script

Microglia In Vitro Activation in Fig 2 and Ext Data Fig 10: link | script

RNA sequencing of neonatal microglia in Fig 2: link | script

Disease enrichment of DEGs Fig 2g:

ATAC Sequencing in Fig 3 & Ext Data Fig 6:

  • ATAC: link | script
  • Validation by Gene Expression: link | script
  • PECA Network Analysis in Ext Data Fig 6: link
  • CUT&RUN Validation Analysis in Ext Data Fig 6: link | script

Rescue of Microglia Blunting with Prenatal Microglia Replacement in Fig 4 and Ext Data Fig 8

Validation of the rescue of microglia bluting using protein expression Fig 4-5: link | script

MSN Electrophysiology Fig. 5, Ext Data 9:

No Effect of Sex by qPCR Ext Data Fig 10: link | script