All Analyses are in gh-pages branch
Results and Scripts for Hayes et al. 2022 Nature can be found here: https://lindsaynhayes.github.io/Hayes_2022/
RNA sequencing analysis of microglia in Fig 1 & Ext Data Fig 1-3:
- MACS-MG Adult LPS Response: link | script
- FACS-MG Blunting: link | script
- Cell Type Heatmap_MACS: link | script
- Volcanos: link | script
- Cell Type Heatmap_FACS: link | script
- Regional MG Blunting: link | script
MIA IL-6 serum resonse to LPS Fig 1g: link | script
MIA microglia morphology in Fig 1 & Ext Data Fig 4:
Single Cell RNA sequencing in Fig 1, 4, & Ext Data 5: script
Microglia In Vitro Activation in Fig 2 and Ext Data Fig 10: link | script
RNA sequencing of neonatal microglia in Fig 2: link | script
Disease enrichment of DEGs Fig 2g:
- ADHD: link | script
- ASD: link | script
- BP: link | script
- MDD: link | script
- SZ: link | script
- multiple comparison correction: link | script
ATAC Sequencing in Fig 3 & Ext Data Fig 6:
- ATAC: link | script
- Validation by Gene Expression: link | script
- PECA Network Analysis in Ext Data Fig 6: link
- CUT&RUN Validation Analysis in Ext Data Fig 6: link | script
Rescue of Microglia Blunting with Prenatal Microglia Replacement in Fig 4 and Ext Data Fig 8
- Prenatal Microglia Ablation and Replacement: link | script
- 3 Hour Maternal Serum: link | script
- Amelioration of Microglia Blunting: link | script
- Rescue PCA: link | script
- Rescue volcanos: link | script
Validation of the rescue of microglia bluting using protein expression Fig 4-5: link | script
MSN Electrophysiology Fig. 5, Ext Data 9: