Alcohol Related Liver Disease (ALD) project
- Link to repository: github.com/llniu/ALD-study
- Link to nature medicine artickle: Noninvasive proteomic biomarkers for alcohol-related liver disease
- summary of scripts used for diverse analysis in the project
- 459 ALD patients (to varying degrees) and 137 age-, bmi-, and gender matched healthy controls in the discovery cohort
- 63 ALD patients in the validation cohort
- Datasets generated and used in this study include proteomics, clinical data (baseline and follow-up), and liver histology characterization.
Contents
| file | description |
|---|---|
| ALD_ML | Contains data pre-processing, Feature Selection, Cross-Validation runs, Final model calculation and diverse plots. Some functionality is loaded from src |
| ALD_ML_STATA | References to STATA .do files in main folder. Done in hospital on follow-up data. |
| ALD_PA | Contains Proteomics and Clinical data pre-processing, ANCOVA, Partial correlation, Integration between the liver- and plasma proteomes, and plots. |
| ALD_App | Contains interactive data visualization Dash App. |
Nature Medicine article
Niu, L., Thiele, M., Geyer, Philipp E., Rasmussen, D. N., Webel, H. E., Santos, A., Gupta, R., Meier, F., Strauss, M., Kjaergaard, M., Lindvig, K., Jocobson, S., Rasmussen, S., Hansen, T., Krag, A., & Mann, M. (2021). Noninvasive proteomic biomarkers for alcohol-related liver disease Nat Med 28, 1277–1287 (2022). https://doi.org/10.1038/s41591-022-01850-y
Disclaimer
Summary data needed for the Dash app is open-access. The complete plasma proteomics data and clinical data are available from the authors upon reasonable request due to the need to maintain patient confidentiality.
Summary of the study
