This programs (v.0.1) estimates inbreeding depression (directional dominance) from a additive-dominance GWAS summary statistics, using a LD score regression framework. The theory underlying this method is described in Yengo et al. (2021): Genomic partitioning of inbreeding depression in humans, AJHG 2021 doi: 10.1016/j.ajhg.2021.06.005 URL: https://www.sciencedirect.com/science/article/pii/S0002929721002299?via%3Dihub PMID: 34214457 To run the program users need to (1) unzip the ldscore files (current version) (2) run a command like this ./ldscdom --sumstat sumstats.txt --ld-score ukb.ldscore --out myOUTPUT (3) CHeck the help by typing ./ldscdom --help Output: Results will be displayed in the standard output (stdout) and log file. The [--out myOUTPUT] option generates a file named myOUTPUT.ldscdom.log with the results. That file can be read in R as described below: R> results <- read.table("myOUTPUT.ldscdom.log",h=T,stringsAsFactors=F,sep="\t")