/Uniprot-ported-gnomADs

These are dataset of gnomAD missense/nonsenses ported to Uniprot numbering

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Uniprot-ported-gnomADs

These are datasets of gnomAD missense/nonsenses ported to Uniprot numbering.

TL;DR

AIM: I want to copy-paste a snippet and get the data without downloading/pulling the repository.

import requests
from collections import ChainMap
from typing import Dict, List
from typing_extensions import TypedDict  # 3.7 or lower, else just use typing

class GnomadDict(TypedDict):
    id: str
    consequence: str # 'missense_variant' etc.
    type: str # same as the above but missense or nonsense
    description: str
    from_residue: str  # single letter. May be more if weirdo fs
    residue_index: int  # human/fortran index
    to_residue: str
    impact: str # gnomAD verdict
    homozygous: int # N hmz
    frequency: float
    N: int # allele count
    # this is complicated:
    frequencies: Dict[str, float]
    # Re frequencies, https://gnomad.broadinstitute.org/help/ancestry has:
    # African/African American (afr),Amish (ami), American Admixed/Latino (amr), 
    # Ashkenazi Jewish (asj), East Asian (eas), Finnish (fin), Non-Finnish European (nfe) and South Asian (sas)
    # this is important because the human population is not global homogeneous and different ancestries
    # have different frequencies in different countries and admix at different rates not only between but also within.
    # i.e. consagnuity and community segregation mean that you cannot extrapolate from ``frequency``

def get_chunk(i) -> dict:
    url = f'https://github.com/matteoferla/Uniprot-ported-gnomADs/raw/main/uniprot_gnomADs/uniprot_gnomADs.{i}.json'
    response : requests.Response = requests.get(url)
    response.raise_for_status()
    return response.json()

# download the whole thing
uniprot_gnomads: Dict[str, List[GnomadDict]] = dict( **ChainMap(*map(get_chunk, range(0, 21))) )

NB: The data herein is a subset: it is only for protein coding regions and does not contain silent mutations.

They contain the uniprot numbered variants with details of frequency, see the typed dictionary above for more details.

If a specific protein is sough and you cannot be bothered finding its uniprot id, then you can do:

import requests, json
from typing import Dict, List


def retrieve_data(filename: str) -> dict:
    url = f'https://github.com/matteoferla/Uniprot-ported-gnomADs/raw/main/{filename}'
    response : requests.Response = requests.get(url)
    response.raise_for_status()
    return response.json()

gene_name = '👾👾👾'
names2uniprot: Dict[str, str] = retrieve_data('uniprot_gnomADs/taxid9606-names2uniprot.json')
uniprot_id: str = names2uniprot[gene_name]
index: Dict[str, str] = retrieve_data('index.json')
filename: str = index[uniprot_id]
data: GnomadDict = retrieve_data(f'uniprot_gnomADs/{filename}')[uniprot_id]

Mapping

See mapping for Python code

I was told the match up between Uniprot and Ensembl is pretty good. But I never checked...

1,315,425 missense variants in gnomAD match the Uniprot sequence, 380,005 do not.

{'same': 108,519, 'good_change': 143696, 'bad_change': 11974, 'error': 30933}

A major problem I spotted is that some entries have cross-database links to canonical transcripts, whereas in reality it's to other isoforms, so I mistrusted these.

  • 7% of gnomAD canonical VEP annotations do not actually match the current Ensembl canonical.
  • 81% match up between Uniprot and Ensembl —82% between Uniprot and gnomAD.
  • 1% have some missense between gnomAD and Uniprot

3% had just some missenses between the sequences. 3% had differences in the sequences. And less than 1% (44) of the Ensembl canonicals did not have a valid corresponding SwissProt Uniprot entry —SwissProt is curated, Trembl has all the "novel protein". The gnomAD canonicals have 371 (see Table 1).

Using the gnomAD canonical, 1968 protein can be corrected based on the gnomAD canonical (108,519 missenses with unaltered index, 143,690 with a concordant starting residue), 739 has missenses whose positition was the same, while 140 were problematic and could not corrected (Table 2).

Rant

I am not a geneticist. I am a biochemist. I do not really care about transcripts etc. but a big problem is that Ensembl and Uniprot are not the same in many cases when it comes to what is canonical, and, to boot, geneticists, will report not the canonical, but the worst consequence in VEP, which is generally the first in the list, i.e. sorted by ENST, which is meaningless. In Ensembl, the canonical transcript is the longest, in Uniprot, the most common transcriptomically. GTex can be used to check this.

SWIFT and AlphaFold run off Uniprot. Uniprot is curated and awesome for protein. gnomAD is really cool as it tells you want protein missenses are present in the human population, which for the control subset is generally healthy (or healthy carriers). It runs off Ensembl.

Table 1 (unmatched)

There are better ways to match ENSP to Uniprot, but for now by symbol is fine, as only 371 are lost.

ESNP ESNP_len symbol
ENSP00000432016 2617 ANKHD1-EIF4EBP3
ENSP00000016946 1765 RGPD5
ENSP00000415941 1744 C4B
ENSP00000491742 1640 BIVM-ERCC5
ENSP00000355890 1512 EPRS1
ENSP00000364815 1264 VARS1
ENSP00000364794 1262 IARS1
ENSP00000264229 1233 CRACD
ENSP00000378236 1182 STON1-GTF2A1L
ENSP00000377954 1176 LARS1
ENSP00000363654 1103 PALM2AKAP2
ENSP00000299505 1070 GARRE1
ENSP00000413445 1029 ELAPOR2
ENSP00000491516 1027 SCART1
ENSP00000358955 1013 ELAPOR1
ENSP00000371886 1012 JMJD7-PLA2G4B
ENSP00000502797 968 AARS1
ENSP00000380996 962 CRACDL
ENSP00000412130 912 IRAG1
ENSP00000274140 910 MARCHF6
ENSP00000262027 900 MARS1
ENSP00000463080 846 MARCHF10
ENSP00000346916 842 TRIM6-TRIM34
ENSP00000242786 835 ADGRE5
ENSP00000369897 831 CARS1
ENSP00000338093 802 TARS3
ENSP00000307567 775 QARS1
ENSP00000419005 756 UTP25
ENSP00000383996 752 CERT1
ENSP00000400168 749 ATP5MF-PTCD1
ENSP00000441269 748 SLCO1B3-SLCO1B7
ENSP00000490573 712 TCAF2C
ENSP00000386830 704 MARCHF7
ENSP00000231572 660 RARS1
ENSP00000313500 647 HROB
ENSP00000491279 638 KDM4F
ENSP00000349458 632 CILK1
ENSP00000380427 625 ARPC4-TTLL3
ENSP00000500220 614 ARSL
ENSP00000433415 602 NT5C1B-RDH14
ENSP00000411848 573 MARCHF8
ENSP00000354732 564 PRR5-ARHGAP8
ENSP00000295966 563 CFAP20DC
ENSP00000489685 560 IQANK1
ENSP00000358939 536 SARS1
ENSP00000480571 535 CYP3A7-CYP3A51P
ENSP00000362576 528 YARS1
ENSP00000353355 525 PTGES3L-AARSD1
ENSP00000477920 511 GIMAP1-GIMAP5
ENSP00000330484 511 AMY1B
ENSP00000359100 511 AMY1A
ENSP00000425634 509 HARS1
ENSP00000421868 502 CCDC169-SOHLH2
ENSP00000264161 501 DARS1
ENSP00000346442 499 IRAG2
ENSP00000489658 492 CNTNAP3C
ENSP00000485258 478 PRAMEF9
ENSP00000347495 471 WARS1
ENSP00000447121 471 CHURC1-FNTB
ENSP00000473391 469 COMMD3-BMI1
ENSP00000317579 468 RUSF1
ENSP00000466174 463 ATF7-NPFF
ENSP00000474850 452 TRIM49D1
ENSP00000299957 436 GOLM2
ENSP00000359444 423 HSFX1
ENSP00000323036 418 ACP3
ENSP00000413165 417 CKMT1A
ENSP00000273067 410 MARCHF4
ENSP00000265068 409 CFAP92
ENSP00000488257 407 MAGEB6B
ENSP00000282382 404 TMED7-TICAM2
ENSP00000363984 403 PGAP4
ENSP00000333181 402 MARCHF11
ENSP00000498431 402 SPDYE21
ENSP00000355812 399 CEP43
ENSP00000422907 395 GTF2H2C
ENSP00000293662 395 TAMALIN
ENSP00000498596 379 STING1
ENSP00000267103 376 MYG1
ENSP00000389275 369 NPIPA9
ENSP00000362273 363 ADPRS
ENSP00000262644 359 BPNT2
ENSP00000422067 351 FAM47E-STBD1
ENSP00000466379 348 GET3
ENSP00000319799 346 H1-8
ENSP00000266643 346 MARCHF9
ENSP00000355877 337 MTARC1
ENSP00000355880 335 MTARC2
ENSP00000411822 331 ISY1-RAB43
ENSP00000293826 330 TNFSF12-TNFSF13
ENSP00000429150 324 CYRIB
ENSP00000370724 323 CYRIA
ENSP00000493820 323 OR5D3P
ENSP00000445323 321 ZNF559-ZNF177
ENSP00000357542 318 ZNF511-PRAP1
ENSP00000492889 314 OR1R1P
ENSP00000357731 312 LORICRIN
ENSP00000497734 312 OR51C1P
ENSP00000494254 311 OR5BS1P
ENSP00000493454 310 OR2A1
ENSP00000493452 308 OR9H1P
ENSP00000396755 307 CCNP
ENSP00000443411 304 CIBAR2
ENSP00000370083 294 SMN1
ENSP00000427223 289 MARCHF1
ENSP00000429367 289 CIBAR1
ENSP00000499970 289 NFILZ
ENSP00000351813 278 MARCHF5
ENSP00000251303 275 SLX1A
ENSP00000485259 274 NOTCH2NLR
ENSP00000497977 273 GET1-SH3BGR
ENSP00000498945 265 SPDYE9
ENSP00000334805 255 H1-7
ENSP00000335808 254 PSME3IP1
ENSP00000309141 253 MARCHF3
ENSP00000471536 246 MARCHF2
ENSP00000385560 243 RBAK-RBAKDN
ENSP00000411198 235 KRTAP4-16
ENSP00000492766 233 FOXL3
ENSP00000375656 233 ZNF816-ZNF321P
ENSP00000450085 233 RNASEK-C17orf49
ENSP00000463379 228 RPL17-C18orf32
ENSP00000403937 221 IFTAP
ENSP00000458075 217 BOLA2-SMG1P6
ENSP00000441930 214 DNAAF6
ENSP00000329662 213 H1-10
ENSP00000485552 208 SAA2-SAA4
ENSP00000341214 207 H1-6
ENSP00000326110 206 MACIR
ENSP00000475025 201 TLCD4-RWDD3
ENSP00000362618 200 PABPC1L2A
ENSP00000491873 198 TAF11L10
ENSP00000492874 198 TAF11L5
ENSP00000492752 198 LINC02218
ENSP00000492047 198 TAF11L2
ENSP00000492463 198 TAF11L9
ENSP00000491174 198 TAF11L8
ENSP00000492787 198 TAF11L3
ENSP00000491846 198 TAF11L11
ENSP00000461830 198 CEP20
ENSP00000491332 198 TAF11L13
ENSP00000491494 198 TAF11L4
ENSP00000491758 197 TAF11L12
ENSP00000491472 197 TAF11L14
ENSP00000491663 194 SSU72P4
ENSP00000492512 194 SSU72P8
ENSP00000491894 194 SSU72P7
ENSP00000491768 194 SSU72P3
ENSP00000491949 194 SSU72P5
ENSP00000491669 194 SSU72P2
ENSP00000494697 192 RPL9
ENSP00000471224 192 DMRTC1
ENSP00000276927 189 IFNA1
ENSP00000469011 188 SSX4
ENSP00000479168 187 PRH1
ENSP00000424176 179 EPPIN-WFDC6
ENSP00000496813 174 GET1
ENSP00000301408 165 CGB5
ENSP00000349954 165 CGB3
ENSP00000429865 164 TVP23C-CDRT4
ENSP00000359434 158 EOLA2
ENSP00000454021 155 TGIF2-RAB5IF
ENSP00000501406 153 TUG1
ENSP00000497053 147 H3Y2
ENSP00000354723 147 H2BW1
ENSP00000322421 142 HBA1
ENSP00000333277 136 H3C13
ENSP00000367891 136 LGALS7
ENSP00000496014 136 H3Y1
ENSP00000484638 136 H3C8
ENSP00000355780 136 H3-3A
ENSP00000366999 136 H3C4
ENSP00000480826 136 H3C1
ENSP00000484841 136 H3C2
ENSP00000484658 136 H3C3
ENSP00000484095 136 H3C7
ENSP00000483283 136 H3C11
ENSP00000358160 136 H3C10
ENSP00000489282 136 H3C6
ENSP00000355657 136 H3-4
ENSP00000339835 135 H3-5
ENSP00000445831 134 H2BC18
ENSP00000297012 131 H2AC1
ENSP00000351589 130 H2AC13
ENSP00000483842 130 H2AC4
ENSP00000352119 130 H2AC11
ENSP00000482538 130 H2AC16
ENSP00000367022 130 H2AC6
ENSP00000482431 130 H2AC15
ENSP00000355656 130 H2AW
ENSP00000332790 130 H2AC21
ENSP00000368747 130 TRBV20OR9-2
ENSP00000438553 129 H2AJ
ENSP00000332194 129 H2AC20
ENSP00000308405 128 H2AZ2
ENSP00000366679 128 H2AC12
ENSP00000491733 127 CSAG2
ENSP00000289316 126 H2BC5
ENSP00000479284 126 H2BU1
ENSP00000489317 126 H2BC6
ENSP00000445633 126 H2BC8
ENSP00000477527 126 H2BC17
ENSP00000321744 126 H2BC4
ENSP00000479169 126 H2BC9
ENSP00000348924 126 H2BC7
ENSP00000358151 126 H2BC21
ENSP00000482674 126 H2BC3
ENSP00000455596 124 TP53TG3D
ENSP00000496189 120 TINCR
ENSP00000474509 119 IGHV3OR15-7
ENSP00000474384 119 IGHV2OR16-5
ENSP00000386655 118 RPL36A-HNRNPH2
ENSP00000498060 118 RAMACL
ENSP00000474814 117 IGHV3OR16-13
ENSP00000474013 117 IGHV3OR16-12
ENSP00000474639 117 IGHV1OR15-9
ENSP00000481738 117 IGHV1OR21-1
ENSP00000374871 117 TRGV1
ENSP00000474395 117 IGKV1OR2-108
ENSP00000374864 117 TRGV10
ENSP00000339511 117 H2AP
ENSP00000474297 116 IGKV3OR2-268
ENSP00000489180 116 ERVK3-1
ENSP00000474941 116 IGHV3OR16-10
ENSP00000474964 116 IGHV3OR16-8
ENSP00000448600 115 TRBV7-1
ENSP00000374919 115 TRBV23-1
ENSP00000374884 115 TRBV7-3
ENSP00000374901 114 TRBV5-7
ENSP00000483468 114 TRBV17
ENSP00000374885 114 TRBV5-3
ENSP00000374896 114 TRBV6-7
ENSP00000482333 114 TRBV15
ENSP00000450448 113 TRAV8-7
ENSP00000473871 110 URGCP-MRPS24
ENSP00000346892 110 SERF1A
ENSP00000359693 108 FKBP1C
ENSP00000367034 103 H4C3
ENSP00000366956 103 H4C8
ENSP00000347168 103 H4C11
ENSP00000480960 103 H4C13
ENSP00000479794 103 H4C12
ENSP00000244537 103 H4C6
ENSP00000479461 103 H4C4
ENSP00000374863 103 TRGV11
ENSP00000479106 103 H4C1
ENSP00000366974 103 H4C2
ENSP00000484789 103 H4C5
ENSP00000481486 103 H4C9
ENSP00000477870 98 H4C7
ENSP00000474363 98 IGHV3OR16-9
ENSP00000347933 96 PLGLB1
ENSP00000490566 79 TMEM238L
ENSP00000334330 78 DEFB105A
ENSP00000492284 76 KANTR
ENSP00000320813 72 DEFB104A
ENSP00000334681 70 DEFB107A
ENSP00000335307 65 DEFB106A
ENSP00000303532 64 DEFB4A
ENSP00000419781 50 IGLJ3
ENSP00000489624 48 TUNAR
ENSP00000418274 47 IGLJ2
ENSP00000499205 33 BLACAT1
ENSP00000490930 25 LINC00672
ENSP00000418818 24 IGLJ5
ENSP00000419267 23 IGLJ6
ENSP00000451143 23 TRAJ52
ENSP00000451312 22 TRAJ45
ENSP00000451561 22 TRAJ28
ENSP00000450593 22 TRAJ2
ENSP00000451299 22 TRAJ53
ENSP00000451503 22 TRAJ32
ENSP00000483197 22 TRAJ37
ENSP00000451639 22 TRAJ18
ENSP00000452134 21 TRAJ24
ENSP00000450455 21 TRAJ23
ENSP00000452510 21 TRAJ39
ENSP00000451066 21 TRAJ10
ENSP00000451965 21 TRAJ6
ENSP00000452097 21 TRAJ4
ENSP00000452149 21 TRAJ41
ENSP00000452565 21 TRAJ1
ENSP00000451248 21 TRAJ38
ENSP00000452484 21 TRAJ13
ENSP00000451250 21 TRAJ17
ENSP00000451843 21 TRAJ22
ENSP00000451870 21 TRAJ56
ENSP00000450777 21 TRAJ48
ENSP00000452150 21 TRAJ58
ENSP00000452248 21 TRAJ57
ENSP00000451191 21 TRAJ46
ENSP00000451632 21 TRAJ44
ENSP00000418697 20 TRGJP2
ENSP00000450953 20 TRAJ26
ENSP00000451766 20 TRAJ9
ENSP00000419223 20 IGHJ6
ENSP00000450961 20 TRAJ5
ENSP00000452114 20 TRAJ40
ENSP00000452464 20 TRAJ61
ENSP00000451806 20 TRAJ11
ENSP00000450522 20 TRAJ12
ENSP00000450622 20 TRAJ16
ENSP00000451589 20 TRAJ50
ENSP00000451728 20 TRAJ19
ENSP00000451140 20 TRDJ3
ENSP00000452115 20 TRAJ25
ENSP00000452564 20 TRAJ54
ENSP00000451221 20 TRAJ27
ENSP00000452518 20 TRAJ29
ENSP00000418089 20 TRGJP
ENSP00000478270 20 TRAJ36
ENSP00000451687 20 TRAJ35
ENSP00000419604 20 TRGJP1
ENSP00000452600 20 TRAJ7
ENSP00000451847 19 TRAJ20
ENSP00000451671 19 TRAJ30
ENSP00000452141 19 TRAJ31
ENSP00000451657 19 TRAJ49
ENSP00000450793 19 TRAJ34
ENSP00000451175 19 TRAJ33
ENSP00000451749 19 TRAJ47
ENSP00000450760 18 TRAJ21
ENSP00000450690 18 TRAJ43
ENSP00000450875 18 TRDJ2
ENSP00000451065 18 TRAJ59
ENSP00000417149 17 TRGJ2
ENSP00000419748 17 IGHJ2
ENSP00000450438 17 TRAJ14
ENSP00000420517 16 IGHJ3
ENSP00000452040 16 TRDJ4
ENSP00000418164 16 IGHJ5
ENSP00000419233 15 IGLJ7
ENSP00000420142 15 TRBJ2-2P
ENSP00000419074 15 IGHJ4
ENSP00000418768 13 IGKJ2
ENSP00000420166 13 IGKJ5
ENSP00000419518 13 IGKJ3
ENSP00000428366 12 IGHD3-16
ENSP00000417097 12 IGKJ4
ENSP00000419997 11 IGLJ4
ENSP00000420442 10 IGHD3-3
ENSP00000474065 10 IGHD2OR15-2A
ENSP00000429952 10 IGHD3-22
ENSP00000427969 10 IGHD2-15
ENSP00000428616 10 IGHD2-8
ENSP00000474133 10 IGHD3OR15-3A
ENSP00000430788 10 IGHD2-2
ENSP00000419583 9 IGHD3-9
ENSP00000429324 9 IGHD2-21
ENSP00000419773 9 IGHD3-10
ENSP00000419564 7 IGHD6-13
ENSP00000419283 7 IGHD5-12
ENSP00000473700 7 IGHD5OR15-5B
ENSP00000418010 7 IGHD6-19
ENSP00000473849 7 IGHD5OR15-5A
ENSP00000417751 6 IGHD6-25
ENSP00000419139 6 IGHD5-24
ENSP00000417892 6 IGHD5-5
ENSP00000430248 6 IGHD4-23
ENSP00000417555 6 IGHD5-18
ENSP00000418151 6 IGHD6-6
ENSP00000420556 5 IGHD1-20
ENSP00000431089 5 IGHD4-17
ENSP00000418765 5 IGHD1-14
ENSP00000474222 5 IGHD1OR15-1B
ENSP00000430034 5 IGHD4-11
ENSP00000420794 5 IGHD1-7
ENSP00000428393 5 IGHD4-4
ENSP00000452494 4 TRDD3
ENSP00000418639 3 IGHD7-27
ENSP00000451515 3 TRDD2

Table 2

Sequences whose alignment prevented a conversion.

symbol gnomAD_ENSP bad_change good_change same
Q6V0I7 FAT4 ENSP00000501473 471 31 0
Q96JP2 MYO15B ENSP00000495242 332 18 0
Q5SNV9 C1orf167 ENSP00000414909 309 29 0
Q9Y2K3 MYH15 ENSP00000273353 283 24 0
P52746 ZNF142 ENSP00000398798 262 13 17
Q96AX9 MIB2 ENSP00000426103 246 20 0
Q07157 TJP1 ENSP00000348416 231 22 0
Q14005 IL16 ENSP00000302935 222 20 0
Q9UKZ4 TENM1 ENSP00000403954 185 9 0
Q6ZSZ5 ARHGEF18 ENSP00000482647 180 11 0
Q5JV73 FRMPD3 ENSP00000276185 179 13 0
Q92538 GBF1 ENSP00000359000 179 18 34
Q12769 NUP160 ENSP00000367721 177 17 0
Q5T6F2 UBAP2 ENSP00000354039 155 20 31
Q9UPX8 SHANK2 ENSP00000345193 151 18 0
Q08379 GOLGA2 ENSP00000478799 151 5 10
P23109 AMPD1 ENSP00000430075 150 7 0
O95785 WIZ ENSP00000263381 143 132 12
Q9H8H2 DDX31 ENSP00000361232 143 2 0
Q6ZP01 RBM44 ENSP00000321179 137 10 0
Q9ULE0 WWC3 ENSP00000370242 136 9 0
Q96T25 ZIC5 ENSP00000267294 121 15 0
Q8NHH1 TTLL11 ENSP00000321346 121 7 0
P46379 BAG6 ENSP00000365131 115 5 20
H3BPF8 GOLGA8S ENSP00000455298 112 10 0
Q8TE49 OTUD7A ENSP00000305926 110 19 31
Q6ZW05 PTCHD4 ENSP00000341914 109 11 0
O14772 FPGT ENSP00000359935 107 8 0
Q5VTQ0 TTC39B ENSP00000422496 106 10 0
P55157 MTTP ENSP00000427679 104 7 0
P29973 CNGA1 ENSP00000426862 104 16 0
Q5T0N1 CFAP70 ENSP00000310829 101 3 11
Q03518 TAP1 ENSP00000346206 101 15 0
O76011 KRT34 ENSP00000377570 101 6 0
A8MY62 LACTBL1 ENSP00000402297 97 7 0
P22105 TNXB ENSP00000407685 95 89 0
Q9BXY5 CAPS2 ENSP00000386959 94 8 0
Q8TDS5 OXER1 ENSP00000367930 93 3 0
Q12894 IFRD2 ENSP00000402849 90 10 0
Q6NUS6 TCTN3 ENSP00000483364 90 2 0
P01019 AGT ENSP00000355627 89 8 0
Q5SQN1 SNAP47 ENSP00000314157 87 3 0
P50747 HLCS ENSP00000502087 87 8 0
P59826 BPIFB3 ENSP00000364643 86 6 0
Q96FT7 ASIC4 ENSP00000350786 86 6 0
Q9Y5X5 NPFFR2 ENSP00000307822 85 2 0
P49761 CLK3 ENSP00000378505 83 2 0
Q9UKU6 TRHDE ENSP00000261180 83 12 0
Q8NH41 OR4K15 ENSP00000304077 82 3 0
Q14241 ELOA ENSP00000395574 80 6 0
Q99705 MCHR1 ENSP00000249016 79 10 0
Q9UF12 PRODH2 ENSP00000301175 78 8 0
Q01433 AMPD2 ENSP00000499465 77 6 0
Q7Z2D5 PLPPR4 ENSP00000359204 77 5 0
P52736 ZNF133 ENSP00000439427 75 8 0
Q6ZUS6 CCDC149 ENSP00000488929 70 4 0
Q15270 NKX1-1 ENSP00000407978 70 6 0
Q6IFG1 OR52E8 ENSP00000444054 69 10 0
Q6ZQW0 IDO2 ENSP00000443432 68 6 0
P03999 OPN1SW ENSP00000249389 68 2 0
Q6NUI2 GPAT2 ENSP00000389395 67 2 33
Q0D2K0 NIPAL4 ENSP00000311687 67 7 0
Q8TE04 PANK1 ENSP00000302108 66 3 0
Q14678 KANK1 ENSP00000477725 65 10 297
Q8NGJ2 OR52H1 ENSP00000493308 65 4 0
Q9HBY8 SGK2 ENSP00000340608 65 2 0
Q8NGV7 OR5H2 ENSP00000347418 65 6 0
Q6P587 FAHD1 ENSP00000372112 61 2 0
Q66PJ3 ARL6IP4 ENSP00000313422 61 3 0
Q96KE9 BTBD6 ENSP00000376337 61 8 0
Q8WUG5 SLC22A17 ENSP00000380437 60 2 0
Q86VX9 MON1A ENSP00000296473 57 8 0
Q8WYJ6 SEPTIN1 ENSP00000324511 56 2 0
Q12983 BNIP3 ENSP00000357625 55 2 0
Q14643 ITPR1 ENSP00000306253 55 4 63
O75319 DUSP11 ENSP00000272444 55 7 0
Q9H2S5 RNF39 ENSP00000244360 54 6 0
P11362 FGFR1 ENSP00000393312 54 0 33
Q9UJX3 ANAPC7 ENSP00000394394 53 2 0
Q2TAM9 TUSC1 ENSP00000350716 52 9 0
Q9NZV7 ZIM2 ENSP00000486502 50 4 1
P0DME0 SETSIP ENSP00000480946 50 6 0
Q8NFV4 ABHD11 ENSP00000222800 50 6 0
Q9HD15 SRA1 ENSP00000337513 50 9 0
Q53RT3 ASPRV1 ENSP00000315383 49 4 0
Q5MJ68 SPDYC ENSP00000366390 48 8 0
Q99871 HAUS7 ENSP00000359230 48 2 0
Q9GZU5 NYX ENSP00000340328 48 6 0
Q8TE02 ELP5 ENSP00000379869 47 1 0
Q9HBW0 LPAR2 ENSP00000443256 46 5 0
Q00532 CDKL1 ENSP00000379176 45 3 0
Q12904 AIMP1 ENSP00000378191 43 2 0
Q8N5Z5 KCTD17 ENSP00000385096 43 4 0
A0A0U1RRI6 CENPVL3 ENSP00000489547 42 0 0
Q96DA0 ZG16B ENSP00000371715 42 0 0
A0PJE2 DHRS12 ENSP00000411565 42 3 0
Q6URK8 TEPP ENSP00000290871 41 6 0
Q6SJ96 TBPL2 ENSP00000247219 40 4 0
P0C1H6 H2BW2 ENSP00000347119 40 5 0
Q9Y233 PDE10A ENSP00000355847 38 2 0
P49842 STK19 ENSP00000364482 38 4 0
O95755 RAB36 ENSP00000263116 38 1 0
O00142 TK2 ENSP00000299697 37 3 0
Q9HDB5 NRXN3 ENSP00000489551 36 3 0
A6NGB0 TMEM191C ENSP00000489706 36 1 0
Q6PFW1 PPIP5K1 ENSP00000400887 36 3 5
O14893 GEMIN2 ENSP00000308533 35 2 0
Q9H7D7 WDR26 ENSP00000498603 35 3 0
B4E2M5 ANKRD66 ENSP00000454770 35 2 0
Q6P4F2 FDX2 ENSP00000377311 33 4 0
P0DO97 CCDC192 ENSP00000490579 33 2 0
Q99766 DMAC2L ENSP00000451583 33 3 0
Q96HE8 TMEM80 ENSP00000380646 33 2 0
Q14203 DCTN1 ENSP00000354791 33 5 148
O43581 SYT7 ENSP00000444201 31 20 11
Q96GE6 CALML4 ENSP00000419081 30 2 0
Q8N8F6 YIPF7 ENSP00000332772 27 2 0
Q9UNG2 TNFSF18 ENSP00000385470 27 2 0
Q8IX19 MCEMP1 ENSP00000329920 26 2 0
P55822 SH3BGR ENSP00000332513 25 2 0
Q8WWG9 KCNE4 ENSP00000281830 25 3 0
Q14626 IL11RA ENSP00000450565 24 5 51
P00387 CYB5R3 ENSP00000354468 23 0 30
Q92782 DPF1 ENSP00000347716 23 2 0
P35030 PRSS3 ENSP00000354280 23 2 0
Q13620 CUL4B ENSP00000384109 20 1 0
A6NJ46 NKX6-3 ENSP00000429553 20 16 0
Q92802 N4BP2L2 ENSP00000382328 19 10 0
A6NNV3 SPDYE16 ENSP00000487772 16 3 0
A1L168 C20orf202 ENSP00000383474 16 2 0
Q5H9F3 BCORL1 ENSP00000437775 15 0 133
Q07654 TFF3 ENSP00000430690 15 1 0
Q8WUH1 CHURC1 ENSP00000475473 14 0 0
P19021 PAM ENSP00000306100 12 1 129
Q8WU43 C2orf15 ENSP00000497775 11 1 0
Q969V6 MRTFA ENSP00000498671 5 0 0
Q16181 SEPTIN7 ENSP00000413507 3 0 0
Q5JWR5 DOP1A ENSP00000237163 1 0 0
Q13347 EIF3I ENSP00000362688 1 1 22
P01861 IGHG4 ENSP00000493388 1 0 134