First, create a virtualenv using python native functionality The purpose is to hold imports and other package dependencies:
$ python3 -m venv py_env
Activate the new virtualenv by doingL
source py_env/bin/activate
While the py_dev is active you'll notice the label "py_dev" on the os prompt.
Now, install the dependencies. In this case, Django.
pip3 install django
pip3 install djangorestframework
pip3 install django-filter
pip3 install markdown
Now use django-admin to setup the project,
django-admin startproject py_clean_arch_rest_api .
and the app
cd py_clean_arch_rest_api
django-admin startapp theapp
From now on implement the app inside "theapp" directory.