about simulated expression

[Lipxiao]

Thank you for your excellent work! However, I have a question regarding simulated expression. Can the simulated expression calculated by CellOracle be considered equivalent to the real expression observed in experiments (e.g., RNA-seq dataset of knockout 'Gata')?

[Lipxiao]

I apologize for my oversight. I found the published paper provides a detailed explanation of this. "This step applies the GRN model as a function to propagate the shift in gene expression rather than the absolute gene expression value, representing the signal flow from TF to target gene."