mpxv-lineages/lineage-designation

Proposal for a B.1 sublineage, circulating in the US (CA/WA) during 2023 [36 seqs]

corneliusroemer opened this issue · 2 comments

corneliusroemer commented

Most of (sequenced) global B.1* circulation in 2023 falls into C.1 or B.1.20.

However, there's a third lineage that's currently part of B.1 that's been sizeable in the US alongside B.1.20 with sequences throughout 2023:

image

Defining mutations (broad):

  • C132698T
  • G22415A (unique, i.e. has not occurred elsewhere within B.1 yet)

All sequences just basal to the lineage are from Portugal. One sequence within the proposed lineage was sequenced in Portugal.

https://next.nextstrain.org/mpox/lineage-B.1?gt=nuc.22415A

mengfeip commented

Is there an update about the above proposed B.1 sublineage circulating in the US 2023? Multiple GISAID sequences from the US circulating in 2023 are within the same cluster.

corneliusroemer commented

Thanks for asking @mengfeip! I will check with the committee/consortium and we'll let you know!