/PD_substantia_nigra

Source code for PD substantia nigra single nucleus RNA-seq data analysis

Primary LanguageR

Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease

This repository contains the source code for analyzing the single nucleus RNA-seq data from Parkinson’s disease and control subject brains (Wang et al 2024). The code can also be found at Zenodo (https://zenodo.org/records/10119032). To use this code, please follow the script order 01 - 06.

Reference

  1. Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, Davis DA, Sun X, Zhang B, Yue Z. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease. Science Advances. 2024;10(2):eadi8287. doi: doi:10.1126/sciadv.adi8287. https://www.science.org/doi/full/10.1126/sciadv.adi8287