Escape or not TBA

[miseminger]

From S_convalescent_plasma_escape.txt
Figure out if these mean better neutralization or worse neutralization:

# In 34 convalescent cases 4–9 weeks following infection in June 2020, before the emergence of B.1.1.7, neutralization titers 
# against B.1.351 were, on average, 13.3-fold reduced compared with an early Victoria sample (p < 0.0001). Significantly, 18 
# of 34 samples failed to reach 50% neutralization at a plasma dilution of 1:20, with a number showing a near total reduction of neutralization activity.
# In 13 convalescent cases 4–9 weeks following infection with B.1.1.7, neutralization titers 
# against B.1.351 were, on average, 3.1-fold reduced compared with an early Victoria sample (p < 0.0001). 
# Zhou et al. (2021) https://doi.org/10.1016/j.cell.2021.02.037 [Journal publication]
D80A;D215G;L242del;A243del;L244del;K417N;E484K;N501Y;D614G;A701V

# Neutralization capacity GMT of 27 subjects' sera post-infection was considerably higher (stronger) than after the second 
# Pfizer dose, and 4.5x drop in B.1.1.7 neutralization was observed.
# Collier et al. (2021) https://doi.org/10.1038/s41586-021-03412-7 [Journal publication]
H69del;V70del;Y144del;N501Y;A570D;P681H;T716I;S982A;D1118H

# Neutralization capacity GMT of 27 subjects' sera post-infection was markedly worse against B.1.1.7 + E484K than the lineage alone, with a 11.4x drop.
# Collier et al. (2021) https://doi.org/10.1038/s41586-021-03412-7 [Journal publication]
H69del;V70del;Y144del;E484K;N501Y;A570D;P681H;T716I;S982A;D1118H

# In convalescent sera one month or more post-infection in Spring 2020, an average 6.5x decrease in reciprocal ID50 value was observed 
# ten key point mutations in Spike in the P.1 lineage vs wildtype. A 3.4x decrease against the full P.1 type vs WA-1 was observed, with 
# better full P.1 ID50 reciprocal value compared to the 10-mutation model.
# Wang et al. (2021) https://doi.org/10.1101/2021.03.01.433466 [Preprint (BioRxiv); Now published at: https://doi.org/10.1016/j.chom.2021.04.007]
L18F;T20N;P26S;D138Y;R190S;K417T;E484K;N501Y;D614G;H655Y

# In a Syrian hamster model, B.1.351 variant virus had >4x reduction in YRNT90 (measure of neutralization) using wild type convalescent sera.
# PG: Note that exact sequence for B.1.351 used was not disclosed.
# Cochin et al. (2021) https://doi.org/10.1101/2021.04.19.440435 [Preprint (BioRxiv)]
D80A,L242del;A243del;L244del;R246I;K417N;E484K;N501Y;D614G;A701V