Is Sequenza suitable for panel sequencing data?
Opened this issue · 0 comments
h170607 commented
Hi, developers
We are now analyzing the purity and ploidy of a set of tumor samples with panel sequencing (over 700 genes). The Sequenza results were obtained using version 3.0.0 with default parameters; the input was generated by the python script sequenza-utils.py version 3.0.0 with default binning size of 50 bases. We found that the purity of most samples was 1 or close to 1, while the results of other software were not.
We want to know if Sequenza is suitable for estimating the purity of panel sequencing, or we need to adjust some parameters to make it fit.
Could you please give us some guidance. Thank you!
best,