Code to reproduce the analysis done in the paper: "A design strategy for improving vaccines via abrogation of host receptor binding" by Ratswohl et al. in EJI.
Relies on deep mutational scanning data from Blooms lab available here:
-
Deep Mutational Scanning data from https://doi.org/10.1016/j.cell.2020.08.012 as
Deep_Mutational_Scan_RBD_stability_ACE2binding.csv -
Anti-body escape data from https://doi.org/10.1016/j.chom.2020.11.007 as
Tableofmutation_antibody-escape_fraction_scores.csv
Using conda the we can set up an environment using
conda create -n bibax python=3.7 numpy scipy matplotlib pandas
We can then activate the environment and run the analysis
conda activate bibax
python analysis-pipeline.py