This is the code and configuration for the paper entitled "Challenges in estimating the effectiveness of COVID-19 vaccination using observational data". This paper compares two approaches to target trial emulation for estimating COVID-19 vaccine effectiveness: the single trial approach and the sequential trial approach.
You can run this project via Gitpod in a web browser by clicking on this badge:
- If you are interested in how we defined our code lists, look in the codelists folder.
- Developers and epidemiologists interested in the framework should review the OpenSAFELY documentation
The project.yaml defines run-order and dependencies for all the analysis scripts.
It is split into a series of "actions", each one implementing a step in the analysis pipeline.
The file is annotated to describe the purpose of each action.
This file is where you should start if you wish to understand the analysis pipeline.
The project.yaml should not be edited directly. To make changes, edit and run the create-project.R script instead.
There is no need to run create_project.R if you are simply cloning this repo.
The OpenSAFELY framework is a Trusted Research Environment (TRE) for electronic health records research in the NHS, with a focus on public accountability and research quality.
Read more at OpenSAFELY.org.
As standard, research projects have a MIT license.