Welcome to the repository for Open Source Antibiotics (OSA) focusing on our first series of molecules targeting Tuberculosis (TB). This project aims to discover and develop new antibiotics by inhibiting Mur ligase enzymes in Mycobacterium tuberculosis.
Our starting point is a series of quinazoline-2,4-dione derivatives, initially identified as inhibitors of bacterial Mur ligases. You can find the data for the Bacterial Mur Ligase Project in this Repository. Inspired by promising initial data, Dr. Guilherme Fernandes joined the team with a postdoctoral fellowship to advance the development of these compounds for TB treatment.
Professor Matthew Todd, University College London
Dr Guilherme Fernandes, University College London
Professor Christopher Dowson, University of Warwick
Dr Adrian Lloyd, University of Warwick
Dr Laura Diaz-Saez, University of Warwick
This is an open-source project, meaning all data, findings, and methodologies are shared openly. We invite you to join us as a full participant. To understand what being part of an open-source project entails, please visit the Open Source Tuberculosis repository page or read this paper outlining the general principles.
Unless otherwise stated, this project is licensed under CC-BY-4.0, meaning you can do whatever you want with the contents, provided you cite OSA.
If you want to get involved, head over to the Wiki tab to learn more about this open-source drug discovery project and the current status of this project.
Join us in the fight against tuberculosis and contribute to groundbreaking antibiotic research!