openvax/ott-wu-2017-data

Machine readable data from "An Immunogenic Personal Neoantigen Vaccine for Melanoma Patients"

ott-wu-2017-data

Machine readable data from An Immunogenic Personal Neoantigen Vaccine for Melanoma Patients

Supplementary information 3

Summary of the number of identified somatic mutations, predicted HLA binders and synthesized immunizing peptides for Patients 1-10

Columns:

* Patient
* Total mutations
* Mutations with more than 1 binder
* Binders predicted (binding affinity <500nM)
* HLA predicted epitopes after filtering
* Number of peptides included in vaccine

Supplementary information 4

Summary of expression and class I prediction related to the immunizing peptides for Patients 1-6

Columns:

* Patient ID
* Immunizing pool
* Gene
* Protein change
* Peptide length
* HLA allele
* Mutated peptides sequence
* Mutated peptidea affinity
* Wild type peptide sequence
* Wild type peptidea affinity
* Immunizing peptide aequence
* Immunizing peptide ID
* EPT peptide ID
* Gene expression (TPM)
* CD8+ T cell reactivity by IFN-g ELISPOT against peptide pulsed autologous APC
* CD8+ T cell reactivity by IFN-g ELISPOT against minigene expressing autologous B cell
* CD8+ T cell reactivity by IFN-g ELISPOT against autologous tumor

Supplementary information 5

Summary of class II prediction related to the immunizing peptides for Patients 1-6

Columns:

* Patient ID
* Gene
* Protein change
* Immunizing peptide ID
* Immunizing peptide
* Binding peptide
* HLA allele
* Prediction method
* Percentile rank

Extended Data Table 1

Patient characteristics

Extended Data Figure 5

Ex vivo CD4+ T cell responses and in vitro stimulated responses for both CD4+ and CD8+ T cells.