This is code of MDLD (“Mask-Guided Target Node Feature Learning and Dynamic Detailed Feature Enhancement for LncRNA-Disease Association Prediction”).
| File_name | Data_type | Description | Source |
|---|---|---|---|
| dis_sim_matrix_process.txt | disease-disease | The file contains the semantic similarities among 405 diseases. The value in i-th row and j-th column is the similarity between the i-th disease di and the j-th disease dj. | MeSH |
| lnc_dis_association.txt | lncRNA-disease | The file includes the known 2687 associations between 240 lncRNAs and 405 diseases. The value in i-th row and j-th column is 1 when the i-th lncRNA li is associated with the j-th disease dj, otherwise it is 0. | LncRNADisease |
| mi_dis.txt | miRNA-disease | The file includes the known 13,559 associations between 495 miRNAs and 405 diseases. The value in i-th row and j-th column is 1 when the i-th miRNA mi is associated with the j-th disease dj, otherwise it is 0. | HMDD |
| lnc_mi.txt | lncRNA-miRNA | The file includes the known 1002 interactions between 240 lncRNAs and 495 miRNAs. The value in i-th row and j-th column is 1 when the i-th lncRNA li is associated with the j-th miRNA mj, otherwise it is 0. | starBase |
| lnc_sim.txt | lncRNA-lncRNA | The file contains the semantic similarities among 240 lncRNAs. The value in i-th row and j-th column is the similarity between the i-th lncRNA li and the j-th lncRNA lj. |
Chen et al. |
| lncRNA_name.txt | lncRNA | It contains the names of 240 lncRNAs. | LncRNADisease |
| disease_name.txt | disease | It contains the names of 405 diseases. | LncRNADisease |
(1) Chen, X., Clarence Yan, C., Luo, C. et al. Constructing lncRNA Functional Similarity Network Based on lncRNA-Disease Associations and Disease Semantic Similarity. Sci Rep 5, 11338 (2015).
-utils : data preprocessing,parameters et al.
-data : Dataset used in the research
-models : scripts for implementation of the model
-main : scripts for model training and testing packages:
python == 3.9.0
torch == 1.13.0
numpy == 1.23.5
scikit-learn == 1.2.2
scipy == 1.10.1
pandas == 2.0.1
matplotlib == 3.7.1python ./main.py