PMI-0.4-Runtime-Demo ==================== PMI version for basic perfusion analysis in DCE-MRI, DSC-MRI and DCE-CT. Source: PMI-0.4/Packages/Menus/PMI__Menu__Demo.pro -------------------------------------------------------------------------- Author: Steven Sourbron Email: s.sourbron@leeds.ac.uk Software page: https://sites.google.com/site/plaresmedima Personal page: http://medhealth.leeds.ac.uk/profile/500/407/steven_sourbron --------------------------------------------------------------------------- Functionality ============= Skeleton menu Slices menu Dynamics menu Perfusion menu Semi-quantitative (Pixel) ------------------------- Calculates maps of three semi-quantitative parameters, ie. - Maximum Enhancement (a measure of perfusion) - Area under the curve (a measure of distribution space) - The ratio Area/maximum (a measure of mean transit time) Source: PMI-0.4/Packages/Perfusion/Buttons/PMI__Menu__SemiQuantitativePerfusion.pro Model-free (Pixel) ------------------ Calculates maps of three quantitative parameters using model-free deconvolution (Ostergaard et al MRM 1996): - Tissue plasma Flow (ml/min/100g) - Extracellular volume (% or ml/100g) - Mean Transit Time (sec) Note: the volume (or MTT) equals plasma volume (or plasma MTT) when an intravascular indicator is used, or when the indicator does not leak due to physiological barriers (ie. BBB). In all other conditions these parameters characterise the entire extracellular space. Source: PMI-0.4/Packages/Perfusion/Buttons/FastDeconvolutionAnalysis.pro Modified Tofts (Pixel) ---------------------- Calculates maps of Ktrans, kep and ve using a linearised fit for the modified Tofts model (Murase et al MRM 2004). Source: PMI-0.4/Packages/Perfusion/Buttons/FitModToftsLin.pro Exchange models (ROI) --------------------- Offers fits on ROI basis to a set of models that apply to tissue composed of vascular-interstitial spaces with symmetric exchange between them. The choice of model is interactive: - Maximum slope - Uptake - Steady State - Patlak - Model-free - Compartment - Tofts - Modified Tofts - Modified Tofts (Linear) - 2-compartment uptake - 2-compartment exchange Note: for a detailed discussion of these models and nomenclature, see Sourbron and Buckley NMR Biomed 2013. Source: PMI-0.4/Packages/Perfusion/Buttons/FitSingleInletRoi.pro Kidney models (ROI) ------------------- Offers fits on ROI basis to a set of models that apply to renal cortex regions (or voxels), or whole-kidney regions: - Maximum slope - Model-free - Patlak - Modified Tofts - 2-compartment uptake - 2-compartment Filtration Note: A discussion of these models and nomenclature can be found in Sourbron et al Invest Radiol 2008 Source: PMI-0.4/Packages/Perfusion/Buttons/KidneyModelsROI.pro Liver models (ROI) ------------------ Offers fits on ROI basis to a set of dual-inlet models that apply to liver parenchyma. Fitting of delays is optional and either of the inlet functions can be turned on/off interactively. The following dual-inlet models are implemented: - One compartment - Patlak - Modified Tofts - Uptake - Exchange - Exchange-Uptake Note: Some discussion on nomenclature can be found in Sourbron et al Radiology 2012. The Patlak, Modified Tofts and Uptake models use a nomenclature designed for Gadoxetic acid; they assume the central compartment is the extracellular space (plasma and interstitium) and the second compartment is the intracellular space. The exchange model describes exchange between plasma and interstitium without involvement of an intracellular space The exchange-uptake model is three-compartmental (plasma, interstitium, intracellular). These last two models are likely to be overparametrized in most situations. Source: PMI-0.4/Packages/Perfusion/Buttons/FitDualInletRoi.pro