GSUB (Gwas-by-SUBtraction) is a command line tool to perform GWAS-by-subtraction. It uses closed-form solutions to estimate the associations between each SNP and the two latent components for two traits (i.e.,
Please see the wiki for the detailed manual of GSUB
.
- September 19, 2023: Initial release.
If you use GSUB, please cite:
Wu et al. (2023). Pervasive biases in proxy GWAS based on parental history of Alzheimer's disease. bioRxiv 2023.10.13.562272.
For questions and comments, please open a Github issue (preferred) or contact Yuchang Wu at ywu423@wisc.edu or Stephen Dorn at svdorn@wisc.edu.