rli012/Biopharma

Biopharma

Companies

• AbbVie
• Amgen
• AstraZeneca
• Bristol Myers Squibb/BMS
• Eli Lilly
• Genentech
• Gilead Sciences
• GlaxoSmithKline/GSK
• Johnson & Johnson
• Merck/MSD
• Novartis
• Novo Nordisk
• Pfizer
• Roche
• Sanofi

FDA: The Drug Development Process

Bin Chen Lab @ MSU

转化医学网

Drug databases

• Drug Infromation Portal

• Drug Central

• Drugs@FDA Data Files

• Drugs@FDA: FDA-Approved Drugs

• Drugs.com

• WebMD

• MedlinePlus

• RxList

• DrugBank

Disease

General

A chronic inflammatory disorder affecting many joints, including those in the hands and feet.
In rheumatoid arthritis, the body's immune system attacks its own tissue, including joints. In severe cases, it attacks internal organs.

Sympotoms

Rheumatoid arthritis affects joint linings, causing painful swelling. Over long periods of time, the inflammation associated with rheumatoid arthritis can cause bone erosion and joint deformity.
Pain areas: in the joints, back, or muscles
Joints: stiffness, swelling, tenderness, or weakness
Whole body: fatigue, anemia, or malaise
Skin: lumps or redness
Hand: bump on the finger or swelling
Also common: flare, dry mouth, physical deformity, or sensation of pins and needles

Treatments

While there's no cure for rheumatoid arthritis, physiotherapy and medication can help slow the disease's progression. Most cases can be managed with a class of medications called anti-rheumatic drugs (DMARDS)

Stats

More than 200,000 US cases per year

Pathogenesis

Diagnosis

Stratification

Prognosis

Association with Disease Scores

Association with Drug Response

Target Gene/Pathway

Combination Therapy

Preclinical Animal Models

• Rat
• Mouse
• Monkey
• Dog
• Woodchuck

Cell Lines

• Hot Tumor
• Cold Tumor

New technologies

• Single Cell Sequencing
• Real World Data
• TCR-Antigen Map