See corona.py
- How is orf1ab cleaved into polypeptides? Can we predict this from the sequence?
- How do the researchers know (guess?) where orf1ab cleaves?
- nsp3 and nsp5 do it -- https://www.pnas.org/content/pnas/103/15/5717.full.pdf
- Which protein is the immune system responding to?
- "spike" and "nucleocapsid" -- http://www.cmi.ustc.edu.cn/1/3/193.pdf
- Find the "furin cleavage site" in the "spike glycoprotein"
- It might be at the "PRRA" -- https://www.sciencedirect.com/science/article/pii/S0166354220300528
- Use ProP or PiTou to predict? -- https://en.wikipedia.org/wiki/Furin
- Automatic extraction of genes from different coronaviruses
- Good multisequence compare tool
- Molecular dynamics?
- https://siasky.net/bACLKGmcmX4NCp47WwOOJf0lU666VLeT5HRWpWVtqZPjEA
- Based on injecting DNA (plasmid) that expresses the spike protein