ronboger's Stars
clarafy/conformal-for-design
jasonkyuyim/multiflow
microsoft/protein-transfer
tymor22/protein-vec
Repository for Protein-Vec, a protein embedding mixture of experts model
Dunni3/keypoint-diffusion
A diffusion model for structure-based drug design with faster inference from learned representations of protein structure.
NREL/EvoProtGrad
Directed evolution of proteins in sequence space with gradients
aangelopoulos/conformal-prediction
Lightweight, useful implementation of conformal prediction on real data.
chloechsu/combining-evolutionary-and-assay-labelled-data
nahid18/Awesome-LatchBio
A curated list of awesome Bioinformatics pipelines and software available on LatchBio
ladamalina/coursera-startup
Startup Engineering. Lecture Slides (june 2013)
CovertLab/WholeCellEcoliRelease
Release of the whole cell E. coli model.
metterklume/chessputzer
Image recognition for chess positions
MorganLevineLab/PC-Clocks
Code for the calculation and implementation of the PC Based epigenetic clocks
Mudasirrr/Solidity-SmartContract-Programming
I'm going to share you how to get started programming with the Solidity so that you can become a blockchain developer. I'll show you how to write Ethereum smart contracts with Solidity as a beginner! You don't have know anything about the language to get started with this tutorial. We'll even do all the programming inside your web browser so you won't have install any development tools or anything like that.
NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273
RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.
KengoA/fantasy-basketball
Scraping statistics, predicting NBA player performance with neural networks and boosting algorithms, and optimising lineups for Draft Kings with genetic algorithm
polywrap/wrap-cli
Used to create, build, and integrate wraps.
dynverse/dyngen
Simulating single-cell data using gene regulatory networks 📠
ncborcherding/scRepertoire
A toolkit for single-cell immune profiling
cole-trapnell-lab/garnett
Automated cell type classification
wheaton5/souporcell
Clustering scRNAseq by genotypes
Fmstrat/winapps
Run Windows apps such as Microsoft Office/Adobe in Linux (Ubuntu/Fedora) and GNOME/KDE as if they were a part of the native OS, including Nautilus integration.
Natarajanlab/Single-cell-regulatory-network
Rolstenhouse/unofficial-apis
A collection of unofficial apis. Designed to inspire your next Friday night hack
aspuru-guzik-group/selfies
Robust representation of semantically constrained graphs, in particular for molecules in chemistry
LeelaChessZero/lczero-training
For code etc relating to the network training process.
LeelaChessZero/lc0
The rewritten engine, originally for tensorflow. Now all other backends have been ported here.
taki0112/UGATIT
Official Tensorflow implementation of U-GAT-IT: Unsupervised Generative Attentional Networks with Adaptive Layer-Instance Normalization for Image-to-Image Translation (ICLR 2020)
NVIDIA-Genomics-Research/AtacWorks
Deep learning based processing of Atac-seq data
CamDavidsonPilon/Probabilistic-Programming-and-Bayesian-Methods-for-Hackers
aka "Bayesian Methods for Hackers": An introduction to Bayesian methods + probabilistic programming with a computation/understanding-first, mathematics-second point of view. All in pure Python ;)