ryanlayer/giggle

Feature request - custom background

pfsulliv opened this issue · 0 comments

Added here at Ryan Layer's request.

The current comparisons for the association of bed file A with B appear to be vs the whole genome. What about allowing the user to supply a superset bed file of genomic regions to use (or to exclude) in the comparison? For instance:

  • a lot of the genome is dark (centromeres, stalks, acen, etc) - I may wish to focus just on higher confidence regions;
  • for many comparisons, might want to only look at autosomes as sex chr may be less confident
  • I may want to look at the overlap of brain open chromatin and the transcript start sites of brain expressed genes (±2 kb) but only in the superset of open compartments (a nuanced way to look at region specific ATAC-seq, RNA-seq, and Hi-C results) (for example)

thx! pfs