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Gene lists related to cancer immunotherapy

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gene-lists

Gene lists related to cancer immunotherapy

Class I MHC antigen presentation

Last updated: July 21st, 2018

Sources:

Interferon-gamma response

Last updated: July 21st, 2018

Sources:

  • Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
    • "JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter"
    • "PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter"
    • "the suppressor of cytokine signaling protein family (SOCS; mostly SOCS1 and SOCS3) are involved in negative feedback regulation of cytokines that signal mainly through JAK2 binding, thereby modulating the activity of both STAT1 and STAT3"
  • Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
    • "resistance-associated loss-of-function mutations in the genes encoding interferon-receptor–associated Janus kinase 1 (JAK1) or Janus kinase 2 (JAK2), concurrent with deletion of the wild-type allele"
  • SOCS, inflammation, and cancer
    • "Abnormal expression of SOCS1 and SOCS3 in cancer cells has been reported in human carcinoma associated with dysregulation of signals from cytokine receptors"

Recurrently mutated cancer genes

Last updated: July 21st, 2018

Cancer genes and recurrent mutations extract from Comprehensive Characterization of Cancer Driver Genes and Mutations.

Genes extracted from Table S1 into cancer-driver-genes.csv. Mutations extracted from Table S4 into cancer-driver-variants.csv.

Both datasets were annotated with Ensembl IDs using Ensembl release 92.