zNormalization
mniederhuber opened this issue · 2 comments
mniederhuber commented
Howdy! This has been bugging me. What's the logic to z-normalize by chromosome arm and not whole genome?
Was that just because it's convenient to use seqnames which split by arm?
snystrom commented
Hey! No, it's because there's variable coverage per arm. If you compute mean(coverage) for: dm6, [chrX, chr2, chr3, chr4], and [chrX, chr2L, chr2R, chr3R, chr3L, chr4] you'll see high variance between each.
mniederhuber commented
ah! good to know. Thank you!