/WGR-with-data-from-heterogeneous-populations

WGR-with-Data-from-Heterogeneous-Populations

Project Pipeline

  1. QC protocol for [ARIC] (http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000398.v3.p1)
  2. Perform QC and get final set of genotypes and phenotypes
  3. Finalize simulation protocol and run simulations at varying marker-effect correlations and trait heritabilities
  4. Perform all analyses with GWAS-significant SNPs only with varying -logP-value cutoffs for four phenotypes that have varying heritabilities: Height, HDL, LDL, and Serum Urate
  5. Perform analyses with the fully available marker dataset and compare race-specific heritability estimates and marker-effect correlations to those from GWAS-significant markers only
  6. Some preliminary results can be found here