Key difference between single cell hic and normal population hic in terms of building 3D model

[kainblue]

Hi Longzhi,

I really appreciate all the help you provide. I really like the 3D model you build in the original science paper. Now the biggest question in my mind is can I apply dip-c software on normal population hic? If not, what would be the key hurdle for preventing that happen?

Thanks

Bo

[tanlongzhi]

Hi Bo,

Please see my explanation in this thread.

In general, it's much easier to 3D-model single-cell data, because only a single 3D structure exists. However, there're already many papers on 3D-modeling bulk data. Two researchers I personally know are Irene Farabella and Bin Zhang; but there're plenty more working on bulk Hi-C.

[kainblue]

Thank you so much for pointing me to the right direction! I will look into the their work!

Bo