ssemQr is a package that ultilizes the Proximal Alternating Linearized Maximal to solve the
non-convex non-smooth sparse structrual equation model for identification trans-eQTLs via joint eQTL mapping and
inferring Gene Regulatory Network(GRN).
To install ssemQr, you need a C++ compiler such as g++ or clang++ with C++11 feature,
and for Windows users, the Rtools
software is needed (unless you can configure the toolchain by yourself).
The installation follows the typical way of R packages on Github:
library(devtools)
install_github("Ivis4ml/ssemQr")ssemQr package will be uploaded on CRAN later. Then you can install it via CRAN
install.packages("ssemQr")Xin Zhou, Xiaodong Cai, Joint eQTL mapping and inference of gene regulatory network improves power of detecting both cis- and trans-eQTLs, Bioinformatics, Volume 38, Issue 1, 1 January 2022, Pages 149–156, https://doi.org/10.1093/bioinformatics/btab609
Special thanks must go to Yilun Zhang 3100105044@zju.edu.cn for his contribution to the numerical optimization for the code and mathematical parts of the research.