How to define the high confidence set of regions showing clear changes?

[biozzq]

Dear all,

How to obtain the most different chromatin contact according to chess sim results. According to your Nature Genetics paper, I think that a lower z-ssim (the most import parameter) and higher SN (the second parameter) could represent the higher confidence. Is this right? Thank you very much.

Sincerely,
Zheng zhuqing

[nickmachnik]

Hi @biozzq ,
that is right, the regions with the clearest changes should be the ones with the lowest similarity (i.e. lowest z-ssim or ssim, that should be the same), and highest SN.
Best,
Nick

[biozzq]

Hi @nickmachnik
Thank you.
Best,
Zheng zhuqing