Screenshot of prototype-ish GUI Layout:
http://i.imgur.com/JiIs4.png

Pseudo-usage-example:
private Array<Layout> layouts;
String activeLayout;

@Override
public void create() {
setLayout("mainmenu");
}

private void update() {
    if(getLayout("mainmenu").onClick("btnStartGame"))
        setLayout("game");
}

private Layout getActiveLayout() {
    return getLayout(activeLayout);
}

private Layout getLayout(String layoutTitle) {
for (Layout l : layouts) {
   if (l.getTitle().compareTo(activeLayout) == 0)
             return l;
    }
    return null;
}

private void setLayout(String layoutName) {
    if (getLayout(layoutName)==null) {
        Layout newLayout = Layout.load("layouts/"+layoutName+".layout");
        newLayout.initialize();
        layouts.add(newLayout);
    }
    activeLayout = layoutName;
}

@Override
private void render() {
update();
Gdx.gl.glClearColor(0.2f, 0.2f, 0.2f, 1);
Gdx.gl.glClear(GL10.GL_COLOR_BUFFER_BIT);
batch.setProjectionMatrix(camera.combined);
batch.start();
getActiveLayout().render(batch);
batch.end();
}