/ProtonTherapy-TCP-Relapse-SecondCancer

We incorporated tumour relapse kinetics into the TCP framework and calculate the associated second cancer risks. To calculate proton therapy-induced secondary cancer induction, we used the well-known biologically motivated mathematical model, initiation–inactivation–proliferation formalism. We used the available in vitro data for the linear energy transfer (LET) dependence of cell killing and mutation induction parameters.

Primary LanguageMATLAB

ProtonTherapy-TCP-Relapse-SecondCancer

We incorporated tumour relapse kinetics into the TCP framework and calculate the associated second cancer risks. To calculate proton therapy-induced secondary cancer induction, we used the initiation–inactivation–proliferation formalism, and in-vitro data to model the linear energy transfer (LET) dependence of cell killing and mutation induction parameters. As a clinical application, we employed the mathematical model to Hodgkin's Lymphoma patient data.

https://academic.oup.com/imammb/article-abstract/35/3/347/3925038?redirectedFrom=fulltext