Proton pump inhibitor use in patients with metastatic prostate cancer: individual participant-level meta-analysis of randomized clinical trials
This repository contains the R code used for the post-hoc analysis presented in the research paper "Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials." The study examines the impact of concomitant proton pump inhibitor (PPI) use on the survival of patients with metastatic prostate cancer treated with androgen deprivation therapy (ADT) and abiraterone acetate plus prednisone (AAP).
LATITUDE trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1704174
COU-AA-301 trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1014618
COU-AA-302 trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1209096
This post-hoc study assesses the association between PPI use and survival in patients with metastatic prostate cancer treated with ADT alone or in combination with AAP. The analysis is based on pooled data from the LATITUDE, COU-AA-301, and COU-AA-302 trials. Restricted mean overall survival time (RMOST) and restricted mean progression-free survival time (RMPFST) were compared between PPI users and non-users using inverse probability of treatment weight (IPTW)-adjusted Kaplan-Meier curves and Cox proportional hazards regression models.
The study has been published in Prostate Cancer and Prostatic Diseases and is available at the following link: https://www.nature.com/articles/s41391-023-00695-x.