Single-cell analyses of PBMC from COVID-19 and healthy controls of Japanese

Overview

This repository provides code used for single-cell transcriptome and T/B cell receptor analyses of > 895,000 peripheral blood mononuclear cells from 73 COVID-19 patients and 75 healthy controls of Japanese with host genetics data.

Edahiro R, Shirai Y, et al, "Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity", Nature Genetics in press.

Data availability

Raw sequencing data of scRNA-seq are available at the Japanese Genotype-phenotype Archive (JGA) with accession codes JGAS000593/JGAD000722. A part of the raw scRNA-seq data (nCOVID-19 = 30, nControl = 31) has already been deposited and is available under controlled access at JGA with accession codes JGAS000543/JGAD000662. All the raw sequencing data of scRNA-seq can also be accessed through application at the NBDC with the accession code hum0197. Genotype data of the subjects are available at European Genome-Phenome Archive (EGA) with the accession code EGAS00001006950.

Contact

Ryuya Edahiro: redahiro_at_sg.med.osaka-u.ac.jp