AlexandrovLab/SigProfilerExtractor

Minimum number of mutations or genome length.

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Hello! I'd like to inquire whether it is advisable to exclusively use a specific gene region in constructing a signature.

Hello, thanks for reaching out. It is not recommended to use a specific gene region for constructing a signature. Signatures are created using WGS or WES data. Additional information can be found at #180, thanks!